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Food and Drug Administration has no regulatory authority to do large comparative reviews of medications By making the packaging less inviting, putting lower-priced items on lower shelves, making it hard to see what company made the product and advertising it as little as possible, they're able to pass the savings on to you. They can sell generics at these low prices because they never spent the money advertising the brand in the first place.
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Read through the mails and you will soon understand that it has nothing to do with commerce or business. Kass says the research team concluded that keeping tuberin "turned down" was like lifting the chemical foot off a brake pedal, triggering super-activity in mTORC1, while in the cells with tuberin "turned on", the brake was pushed harder, and mTORC1 remained inactive despite the stimulating hormones. "Instead of turning mTORC1 off, we had something that looked more like a car brake, that was effective only if the car (mTORC1) was on and active," says Ranek.
Like the many other proteins known to alter tuberin, Ranek found protein kinase G altered tuberin by adding phosphates to it, but in a previously unidentified region that turned out to provide the sought after brake-like effect.